Thank you for being part of the SepTiC team!
For SepTiC, our target is to recruit 3758 participants in 60 sites throughout the UK.
The SepTiC trial is now open to recruitment.
The trial is currently open at 34 sites and has recruited over 510 patients.
We are looking for more sites to join the trial and are currently accepting expressions of interest from participating sites.
Imperial College and the central lab will be closed from the 22nd of December 2025 to the 2nd of January 2026.
Recruitment to the Diagnostic and Fluid interventions will be paused during this period and recruitment to GM-CSF will remain open.
The last day to randomise to the Fluid and Diagnostic intervention and send samples will be the 19th of December 2025 and recruitment will re-start on the 2nd of January 2026.
SepTiC Monthly Q&A Series:
Thursday 11th December 2025 12:00 to 13:00
Joined by Professor Anthony Gordon (Chief Investigator) and the Imperial Critical Care Research Team
See recordings of our previous webinars under the ‘Training Videos’ Tab
Join Zoom Meeting for the SepTiC Monthly Q&A Sessions:
https://imperial-ac-uk.zoom.us/j/93817767036?pwd=SzVFV01uZE8zaUp5dzFmZUdTckhkdz09
Meeting ID: 938 1776 7036
Passcode: 1LmN^L
All the information you need is right here!
SepTiC API Forum:
The SepTiC Trial is registered with the Associate Principal Investigator (PI) Scheme – click here to apply to be an Associate PI
SepTiC API Forum Meeting 11.02.2025
SepTiC Webinar:
SepTiC Webinar Series Schedule
Patient Information Sheet full V3.0 17DEC24
Patient Information Sheet Summary V2.0 17DEC24
Personal legal summary (Relatives) V3.0 17DEC24
Professional legal summary V3.0 17DEC24
Telephone Agreement V2.0 14MAR25
Retrospective PIS full V2.0 17DEC24
Manuals:
Templates:
Pharmacy IMP Accountability Log
Initial Kit Allocation Email Template
SepTiC Fluid Trial Manual v1.0 10.11.2023
SepTiC Fluid Intervention 1 Page Summary
SepTiC eCRF Completion Guidelines v3.0 26.11.2025
SepTiC Sample Manual V2.0 01.10.2024
SepTiC Sample Shipping Form v1.0 28.11.2023
SepTiC Note To File Template v2.0 24.06.2024
SepTiC Randomisation Guide v3.0 01.10.2024
SepTiC Randomisation Crib sheet 1_ v1.0 11.06.2024
SepTiC Randomisation Crib Sheet_2 v3.0 20.05.2025
SepTiC Randomisation and Troubleshooting Guide v1.0 23.04.2025
Patient Information Sheet full
Patient Information Sheet Summary
Personal legal summary ( Relatives)
Sealed Envelope (Unblinded Pharmacist) Training Slides v1.0 14.03.24
Sealed Envelope (Unblinded Pharmacist) Training Log v1.0 14.03.24
Randomisation on OpenClinica Video
Multi factor authentication on OpenClinica Video
Webinars:
SepTiC Virtual Webinar 24.11.23
SepTiC Virtual Q&A Webinar 07.02.24
SepTiC Virtual Q&A Webinar 11.03.24
SepTiC Virtual Q&A Webinar 22.08.24 – Fluid Intervention
SepTiC Virtual Q&A Webinar 18.09.24 – GM-CSF Intervention
SepTiC Virtual Q&A Webinar 08.10.24 – Eligibility
SepTiC Virtual Q&A Webinar 11.11.24 – Data entry
SepTiC Virtual Q&A Webinar 04.12.24
SepTiC Virtual Q&A Webinar 22.01.25
SepTiC Virtual Webinar 11.03.25
SepTiC Virtual Q&A Webinar 12.05.25 – Fluid Intervention
SepTiC Virtual Q&A Webinar 17.06.25
SepTiC Virtual Q&A Webinar 11.11.25 – GM-CSF Intervention
Follow us on Twitter at @septictrial
Download Past Newsletters
List of sites
St Mary’s Hospital, London
Charing Cross Hospital, London
Hammersmith Hospital, London
Queen Alexandra Hospital, Portsmouth
Kings Mill Hospital, Nottinghamshire
Kettering General Hospital, Northamptonshire
Bristol Royal Infirmary, Bristol
James Cook University Hospital, Middlesbrough
St George’s Hospital, London
Russells Hall Hospital, Dudley
Sunderland Royal Hospital, Sunderland
Watford General Hospital, Watford
Derriford Hospital, Plymouth
Kings College London, London
Scunthorpe General Hospital, North Lincolnshire
Royal Stoke Hospital, Stoke-on-Trent
Royal Victoria Hospital, Belfast
Belfast City Hospital, Belfast
Darent Valley Hospital, Dartford
Royal Glamorgan Hospital, South Wales
Southampton General Hospital, Southampton
Musgrove Park Hospital, Somerset
Countess of Chester Hospital, Cheshire
Salford Royal Hospital, Salford
Hull Royal Infirmary, Hull
Royal Victoria Infirmary, Newcastle
Freeman Hospital, Newcastle
Southend University Hospital, Westcliff-On-Sea
Queens Medical Centre, Nottingham
Southmead Hospital, Bristol
Warrington Hospital, Warrington
Huddersfield Royal Infirmary, Halifax
Calderdale Royal Hospital, Halifax
John Radcliffe Hospital, Oxford
For sites: sign up to receive your SepTiC newsletter!
@CHFTResearch
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